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Enhanced Human Memory Consolidation With Post-Learning Stress: Interaction With the Degree of Arousal at Encoding

机译:具有学习后压力的增强型人类记忆整合: 编码时与唤醒程度的交互

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摘要

Abundant evidence indicates that endogenous stress hormones such as epinephrine and corticosterone modulate memory consolidation in animals. We recently provided the first demonstration that an endogenous stress hormone (epinephrine) can enhance human memory consolidation. However, these findings also suggested that post-learning stress hormone activation does not uniformly enhance memory for all recently acquired information; rather, that it interacts with the degree of arousal at initial encoding of material in modulating memory for the material. Here we tested this hypothesis by administering cold pressor stress (CPS) or a control procedure to subjects after they viewed slides of varying emotional content, and assessing memory for the slides 1 wk later. CPS, which significantly elevated salivary cortisol levels, enhanced memory for emotionally arousing slides compared with the controls, but did not affect memory for relatively neutral slides. These findings further support the view that post-learning stress hormone-related activity interacts with arousal at initial encoding to modulate memory consolidation.
机译:大量证据表明,内源性应激激素(例如肾上腺素和皮质酮)可调节动物的记忆巩固。我们最近提供了第一个证明,即内源性应激激素(肾上腺素)可以增强人类记忆的巩固。然而,这些发现还表明,学习后应激激素的激活不能统一地增强对所有最近获得的信息的记忆。相反,它在调制材料的存储时与材料的初始编码时的唤醒程度相互作用。在这里,我们通过在受试者观看情绪变化程度不同的幻灯片后对受试者施以冷压应力(CPS)或控制程序,并在1周后评估该幻灯片的记忆力,来测试该假设。与对照组相比,CPS显着提高了唾液皮质醇水平,增强了对情绪激动的玻片的记忆,但对相对中性的玻片没有记忆。这些发现进一步支持了一种观点,即学习后与压力激素相关的活动在初始编码时与唤醒相互作用,以调节记忆巩固。

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